Your Patient Lost Weight on a GLP-1. Can You Trust the eGFR?
Medscape reports that two small, short randomized trial analyses found no muscle-driven inflation of eGFR with semaglutide. In the SMART analysis of 101 adults with CKD without type 2 diabetes, about 9 kg extra weight loss did not track with eGFR changes. A Danish post hoc analysis of 48 patients saw a small creatinine rise. Clinicians discuss when cystatin C testing may help.
Why it matters: Relevant to Maryland clinicians who monitor kidney function in patients taking GLP-1 drugs, and to adults with chronic kidney disease in medical weight-loss programs.
A summary of another publisher's reporting, written with AI and checked automatically against the story. The reporting belongs to medscape.com. October 6, 2026.